:root{--paper:#f4f1e9;--ink:#17231f;--green:#225b4a;--muted:#66736e;--line:#d8d7ce;--white:#fbfaf6}*{box-sizing:border-box}body{margin:0;background:var(--paper);color:var(--ink);font:16px/1.5 Arial,Helvetica,sans-serif}button,select{font:inherit}button,select,a{touch-action:manipulation}button{cursor:pointer}button:focus-visible,select:focus-visible,a:focus-visible,summary:focus-visible,[tabindex]:focus-visible{outline:3px solid #3569b3;outline-offset:4px}header{height:86px;display:flex;align-items:center;justify-content:space-between;padding:0 4.5%;border-bottom:1px solid var(--line);background:var(--white)}.brand{display:flex;gap:13px;align-items:center;text-decoration:none;color:var(--ink);font:22px Georgia,serif}.brand small{display:block;font:12px Arial,sans-serif;color:var(--muted);margin-top:5px;letter-spacing:.04em}.mark{background:var(--green);color:white;border-radius:50%;height:43px;width:43px;display:grid;place-items:center;font:17px Georgia,serif}.edition{font-size:12px;letter-spacing:.1em;color:var(--muted)}.edition span{margin:0 8px;color:#a4b2ac}main{max-width:1580px;margin:auto;padding:0 4.5%}.intro{display:flex;justify-content:space-between;gap:25px;align-items:center;padding:38px 0 29px}.eyebrow{font-size:12px;letter-spacing:.14em;font-weight:700;color:var(--green);margin:0 0 9px}h1{font:clamp(35px,4.3vw,62px)/1.08 Georgia,serif;letter-spacing:-.035em;margin:0 0 12px}h1 em{color:var(--green);font-weight:400}.intro p:not(.eyebrow){margin:0;color:var(--muted)}.stats{display:flex;gap:30px}.stats>div{display:flex;gap:13px;align-items:center;border-left:1px solid var(--line);padding-left:24px}.stats strong{font:52px Georgia,serif;color:var(--green)}.stats span{font-size:12px;line-height:1.5;color:var(--muted)}.atlas{border:1px solid var(--line);border-radius:20px;overflow:hidden;background:var(--white);box-shadow:0 12px 40px #384b440b}.toolbar{display:flex;align-items:center;gap:20px;padding:22px 26px;border-bottom:1px solid #e5e4dc;flex-wrap:wrap}.toolbar p{margin:2px 0 0;font-size:14px;color:var(--muted)}.country-picker{margin-left:auto;display:flex;align-items:center;gap:10px;color:var(--muted);font-size:14px}select{max-width:235px;padding:9px 30px 9px 12px;border:1px solid var(--line);border-radius:8px;background:#fff;color:var(--ink);font-size:14px}.zoom{display:flex;gap:6px}.zoom button{background:white;border:1px solid var(--line);border-radius:8px;padding:9px 12px;color:var(--green);font-size:14px}.zoom button:hover{background:#e7efea}.zoom #europe{background:var(--green);color:white;margin-right:7px}.mapstage{position:relative;background:radial-gradient(ellipse at 50% 50%,#f6f8f4,#edf2ee);overflow:hidden}#map{display:block;width:100%;height:auto;min-height:330px;touch-action:none}.country{fill:#dbe3dc;stroke:#fff;stroke-width:.6;vector-effect:non-scaling-stroke;cursor:pointer;transition:fill .15s}.country.covered{fill:#c7d8cd}.country:hover,.country.selected{fill:#a5bfae;stroke:#225b4a;stroke-width:1}.graticule{fill:none;stroke:#d4ded7;stroke-width:.45;pointer-events:none}.bubble{cursor:pointer;outline:none}.bubble .disc{fill:var(--c);fill-opacity:.88;stroke:#fff;stroke-width:2;filter:drop-shadow(0 3px 4px #17231f22)}.bubble .hit{fill:transparent}.bubble:hover .disc,.bubble:focus-visible .disc{fill-opacity:1;stroke:#17231f;stroke-width:2.5}.bubble text{font:700 14px Arial,sans-serif;fill:#fff;text-anchor:middle;dominant-baseline:central;pointer-events:none}.leader{stroke:#81938a;stroke-width:.7;pointer-events:none}.mapcaption{position:absolute;bottom:14px;left:22px;font-size:12px;color:#596d61;display:flex;align-items:center;gap:8px;pointer-events:none}.keycircle{width:13px;height:13px;border:1px solid #6f8f7c;border-radius:50%;display:inline-block}.oceanlabel{position:absolute;left:12%;top:64%;font-size:10px;letter-spacing:.24em;color:#8c9c93;pointer-events:none}.maplegend{display:flex;gap:24px;padding:17px 26px;align-items:center;flex-wrap:wrap;font-size:13px}.maplegend span{display:flex;gap:8px;align-items:center}.maplegend i{display:block;width:9px;height:9px;border-radius:50%;background:var(--c)}.maplegend .muted{margin-left:auto;color:var(--muted)}#tooltip{position:absolute;z-index:10;background:#172f25;color:#fff;box-shadow:0 7px 20px #17231f26;border-radius:9px;padding:9px 14px;font-size:14px;pointer-events:none;max-width:240px}#tooltip small{display:block;color:#c6d9cd;font-size:12px}.below{display:grid;grid-template-columns:1fr 1fr;gap:20px;margin:21px 0 29px}.below details{border-bottom:1px solid var(--line);padding:0 0 13px}.below summary{cursor:pointer;color:var(--green);font-size:14px;font-weight:600}.below details p{font-size:14px;color:var(--muted)}a{color:#225b4a}footer{display:flex;justify-content:space-between;padding:0 0 25px;gap:15px;font-size:12px;color:var(--muted)}footer>span:first-child{letter-spacing:.12em}.flaglegend{display:flex;flex-wrap:wrap;gap:8px 14px;padding-top:14px;font-size:13px}.flag{display:inline-block;border-radius:5px;padding:3px 7px;background:#edf0ea;color:#315b49;white-space:nowrap;font-size:12px}.flag.conditional{background:#fff0c8;color:#735100}.flag.editing{background:#ebe5f5;color:#55218f}.flag.cell{background:#e4f0f5;color:#245478}.flag.oncolytic{background:#f7e4ee;color:#8a006d}.flag.safety,.flag.withdrawn{background:#f8e4df;color:#9b401a}.flag.unavailable{background:#e8e8e6;color:#535955}.flag.first{background:#e2ecfb;color:#3569b3}dialog{padding:0;width:96vw;max-width:1550px;max-height:90vh;border:1px solid var(--line);border-radius:18px;background:var(--white);color:var(--ink);box-shadow:0 30px 100px #081b2444}dialog::backdrop{background:#142d24a8;backdrop-filter:blur(5px)}.panelhead{display:flex;justify-content:space-between;gap:20px;padding:27px 30px 12px}.panelhead h2{font:40px Georgia,serif;margin:0}.panelhead p:not(.eyebrow){margin:8px 0 0;color:var(--muted);font-size:14px}.panelhead button{align-self:flex-start;border:1px solid var(--line);border-radius:50%;width:38px;height:38px;background:white;color:var(--green)}.panelnote{margin:0 30px;font-size:14px;color:var(--muted)}.compact{padding:14px 30px 18px}.tablewrap{overflow:auto;max-height:49vh;border-top:1px solid var(--line);border-bottom:1px solid var(--line)}table{border-collapse:separate;border-spacing:0;width:100%;min-width:2300px;text-align:left;font-size:14px}th{position:sticky;top:0;background:#e9eee7;color:#335345;font-weight:700;z-index:2;font-size:12px;letter-spacing:.015em}td,th{padding:15px 16px;border-bottom:1px solid #e1e4dd;vertical-align:top}td:nth-child(2),th:nth-child(2){position:sticky;left:0;background:var(--white);z-index:1;min-width:150px;border-right:1px solid #e1e4dd}th:nth-child(2){z-index:3;background:#e9eee7}td:first-child{min-width:85px}td:nth-child(3){min-width:195px}td:nth-child(6){min-width:180px}td:nth-child(9){min-width:330px}td:nth-child(10){min-width:230px}td small{display:block;color:var(--muted);font-size:12px;margin-top:5px}td .flag{margin:0 4px 5px 0}tr:hover td{background:#f0f4ed}.panelfoot{padding:13px 30px 23px;color:var(--muted);font-size:12px}.panelfoot p{max-width:1100px}.panelfoot a{display:inline-block;margin:0 15px 8px 0}.empty{padding:35px;font-size:16px}.source-list{display:flex;flex-wrap:wrap;gap:10px;font-size:14px;margin:12px 0}.source-list a{margin-right:8px}@media(max-width:1000px){.stats{gap:15px}.stats>div{padding-left:15px;flex-direction:column;align-items:start;gap:0}.stats strong{font-size:38px}.toolbar{gap:12px}.country-picker{margin-left:0}.zoom{margin-left:auto}.edition{display:none}.intro{align-items:start}.maplegend{gap:13px}}@media(max-width:650px){header{height:74px}.brand{font-size:19px}.intro{display:block;padding:27px 0 22px}h1{font-size:38px}.stats{margin-top:23px}.stats>div{flex-direction:row;align-items:center;gap:10px;padding-right:20px}.toolbar{padding:17px}.toolbar>div:first-child{width:100%}.zoom{flex-wrap:wrap;margin-left:0}.country-picker{width:100%;justify-content:space-between}select{max-width:220px}.mapstage{min-height:340px}#map{height:340px;min-height:0}.maplegend{padding:15px}.maplegend .muted{margin-left:0;width:100%}.below{grid-template-columns:1fr}.mapcaption{left:12px;right:12px;font-size:11px}.oceanlabel{display:none}footer{flex-direction:column}.panelhead{padding:22px 20px 10px}.panelhead h2{font-size:30px}.panelnote{margin:0 20px}.compact,.panelfoot{padding-left:20px;padding-right:20px}.tablewrap{max-height:44vh}}@media(prefers-reduced-motion:reduce){*{transition:none!important;scroll-behavior:auto!important}}
.atlas-nav{display:flex;gap:8px;padding:14px 4.5%;border-bottom:1px solid var(--line);background:var(--white)}.atlas-nav button,.compare-toolbar button{border:1px solid var(--line);border-radius:8px;background:transparent;color:var(--green);padding:9px 16px;font-size:14px}.atlas-nav button[aria-current]{background:var(--green);color:white}.atlas-nav button:hover,.compare-toolbar button:hover{box-shadow:inset 0 0 0 1px var(--green)}.platform-link{font:inherit;text-align:left;color:#285894;background:#eaf0f9;border:1px solid #c4d4ec;border-radius:7px;padding:9px 11px;line-height:1.5}.platform-link:hover{background:#dce8f8}.sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}#platformPanel{max-width:1280px}.platform-body{padding:0 30px 28px}.platform-intro{margin:10px 0 6px}.platform-disclaimer,.platform-glossary{color:var(--muted);font-size:14px}.platform-body fieldset{border:0;margin:20px 0;padding:0}.platform-body legend{font-size:14px;font-weight:700;color:var(--green);margin-bottom:9px}.platform-options{display:flex;flex-wrap:wrap;gap:8px}.platform-options label{position:relative;cursor:pointer}.platform-options input{position:absolute;opacity:0}.platform-options span{display:block;padding:9px 13px;border:1px solid var(--line);border-radius:9px;font-size:14px;background:white}.platform-options input:checked+span{background:#e2ecfb;border-color:#3569b3;color:#234e88;box-shadow:inset 0 0 0 1px #3569b3}.platform-options input:checked+span:before{content:'✓ ';font-weight:700}.platform-options input:focus-visible+span{outline:3px solid #3569b3;outline-offset:3px}.platform-options input:disabled+span{opacity:.45;cursor:not-allowed}.compare-toolbar{display:flex;align-items:center;justify-content:space-between;gap:12px;padding:16px 0;font-size:14px}.compare-toolbar button:disabled{opacity:.5;cursor:default}.platform-matrix{overflow:auto;border:1px solid var(--line);border-radius:10px}.platform-matrix table{min-width:580px;table-layout:fixed;font-size:16px}.platform-matrix td,.platform-matrix th{position:static!important;min-width:0!important;padding:15px;line-height:1.55;overflow-wrap:anywhere}.platform-matrix th{font-size:14px}.platform-matrix th:first-child{width:170px}.platform-matrix td{background:var(--white)!important;border-right:1px solid var(--line)}.platform-matrix tbody th{background:#f0f2ec}.platform-details{margin-top:16px}.platform-details summary{cursor:pointer;font-size:16px;color:var(--green);padding:14px 0;font-weight:600}.platform-empty{border:1px dashed var(--line);padding:30px;border-radius:10px;color:var(--muted)}.platform-references{display:flex;gap:12px 22px;flex-wrap:wrap;margin:20px 0;font-size:14px}@media(max-width:650px){.platform-body{padding:0 20px 20px}.compare-toolbar{align-items:flex-start}.platform-matrix table{min-width:720px}.platform-options span{padding:10px}.atlas-nav{padding:12px 4.5%}} 
.atlas-nav{flex-wrap:wrap}.disease-link{font:inherit;text-align:left;color:#225b4a;background:#edf3ee;border:1px solid #c7d8cd;border-radius:7px;padding:9px 11px;line-height:1.5}.disease-link:hover{background:#dfebe1}#diseasePanel{max-width:1320px}.disease-top{padding:0 30px 20px;border-bottom:1px solid var(--line)}.disease-top>p{margin:8px 0 12px}.disease-legend summary{cursor:pointer;font-size:14px;color:var(--green);font-weight:700}.disease-legend p{font-size:14px;color:var(--muted);max-width:1100px}.reference-download{display:inline-block;font-size:14px;margin-top:14px}.disease-layout{display:grid;grid-template-columns:300px minmax(0,1fr);min-height:380px}.disease-sidebar{padding:23px;border-right:1px solid var(--line);background:#f2f3ed}.disease-sidebar>label{display:block;font-size:14px;font-weight:600;margin:0 0 6px}.disease-sidebar input,.disease-sidebar select{width:100%;max-width:none;border:1px solid var(--line);border-radius:7px;padding:10px;font:14px Arial,sans-serif;background:white;margin-bottom:16px}.disease-sidebar input:focus-visible{outline:3px solid #3569b3;outline-offset:2px}.disease-sidebar>button{font-size:14px;border:1px solid var(--line);border-radius:7px;background:white;color:var(--green);padding:8px 11px}#diseaseCount{font-size:14px;color:var(--muted)}#diseaseList{max-height:420px;overflow:auto;padding:0 6px 4px 0}.disease-group{font-size:12px;letter-spacing:.07em;text-transform:uppercase;color:var(--green);font-weight:700;margin:18px 0 8px}#diseaseList button{display:block;width:100%;border:1px solid transparent;border-radius:8px;background:transparent;text-align:left;padding:10px;color:var(--ink);font-size:14px;line-height:1.45;margin:3px 0}#diseaseList button:hover{background:#e6ece3}#diseaseList button[aria-pressed=true]{background:white;border-color:#225b4a;box-shadow:0 2px 8px #17231f08}#diseaseList small{display:block;font-size:12px;color:var(--muted);margin-top:3px}#diseaseDetail{padding:28px 32px;min-width:0}.disease-profile-head h3,.disease-welcome h3{font:32px/1.2 Georgia,serif;margin:8px 0 22px}.disease-tag{float:right;background:#e2ecfb;color:#285894;border-radius:7px;font-size:13px;padding:5px 9px;margin:0 0 10px 10px}.disease-facts{display:grid;grid-template-columns:1fr 1fr;gap:20px;margin:0 0 25px}.disease-facts>div:nth-child(3),.disease-facts>div:last-child{grid-column:1/-1}.disease-facts dt{font-size:14px;font-weight:700;color:var(--green);margin-bottom:5px}.disease-facts dd{margin:0;line-height:1.6}.disease-gt{padding:18px 20px;background:#edf3ee;border-left:3px solid #225b4a;border-radius:0 9px 9px 0}.disease-gt h4,.disease-expanded h4,.disease-sources h4{font-size:16px;margin:0 0 8px}.disease-gt p{margin:0 0 10px}.disease-gt small{color:var(--muted);font-size:13px}.disease-expanded{margin:20px 0;border-bottom:1px solid var(--line);padding-bottom:16px}.disease-expanded summary{font-size:16px;font-weight:600;color:var(--green);cursor:pointer;padding:6px 0}.disease-expanded h4{margin-top:18px}.disease-expanded p{margin:5px 0 14px}.disease-sources a{display:inline-block;font-size:14px;margin:0 15px 8px 0}.disease-sources p{color:var(--muted);font-size:12px}.disease-welcome{padding:35px 0;max-width:480px;color:var(--muted)}@media(max-width:750px){.disease-layout{grid-template-columns:1fr}.disease-sidebar{border-right:0;border-bottom:1px solid var(--line);padding:18px 20px}#diseaseList{max-height:180px}.disease-top{padding:0 20px 18px}#diseaseDetail{padding:24px 20px}.disease-facts{grid-template-columns:1fr}.disease-tag{float:none;display:inline-block;margin:0 0 12px}.disease-profile-head h3{font-size:28px}} 
/* Main map navigation */
.toolbar{gap:16px}.toolbar>div:first-child{flex:1 1 100%}.toolbar .atlas-nav{display:flex;flex:1 1 auto;flex-wrap:wrap;gap:10px;padding:0;border:0;background:transparent}.toolbar .atlas-nav button{padding:13px 21px;border:1px solid #3569b3;background:#e5edf9;color:#234e88;border-radius:10px;font-size:16px;font-weight:600;box-shadow:0 2px 5px #17231f0a}.toolbar .atlas-nav button[aria-current]{background:#3569b3;color:white}.toolbar .atlas-nav button:hover{background:#d6e4f8;box-shadow:0 0 0 1px #3569b3}.toolbar .atlas-nav button[aria-current]:hover{background:#285894}.toolbar .zoom{margin-left:auto}.intro h1{font-size:clamp(35px,3.7vw,56px);max-width:820px}.intro .stats{flex-shrink:0}@media(max-width:1000px){.intro{flex-wrap:wrap}}@media(max-width:650px){.toolbar .atlas-nav{width:100%;gap:8px}.toolbar .atlas-nav button{flex:1 1 auto;padding:11px 12px;font-size:14px}.toolbar .zoom{margin-left:0}.intro h1{font-size:38px}}